Tuesday, February 14, 2017

OBSERVATIONS ON THE PROGRESS OF DEMENTIA: A case Study of my Father




My father is suffering from dementia, a disease that robs the memory by destroying brain cells.  From what I can tell, Alzheimer's is one form of dementia but there are also other causes.   It is generally agreed that Alzheimer’s advances much faster than other forms.  Alzheimer's is a progressive brain disorder that damages and eventually destroys brain cells, leading to memory loss and changes in thinking and other brain functions.  Alzheimer's is fatal, and currently, there is no cure.  Other forms of dementia, on the other hand, may be treatable but are also irreversible.  Treatment of dementia depends on its cause, but in the case of most progressive dementia, there is no cure and no treatment that slows or stops its progression.  However, it is claimed that some drugs have been developed that may temporarily improve the symptoms.  Alzheimer's disease results from the buildup of abnormal proteins in the brain, which leads to the cell death that results in cognitive decline.   Alzheimer's disease Symptoms include:


a)    Memory loss

b)    Disorientation to time and place

c)    Misplacing things

d)    Difficulty performing familiar tasks

e)    Changes in gait or walking

f)    Poor or decreased judgment

g)    Changes in mood or behavior

h)    Changes in personality

i)     Loss of initiative

j)     Problems with language

k)    Problems with abstract thinking



In my father’s case, his main symptom is memory loss.  In symptoms b) through e), if he has any at all, it is because of limited mobility and does not seem to be due to dementia.  Symptoms f) through k) do not apply to him; his mood, behavior and personality have not changed, he has lots of initiative, no problems with language – he is fluent in Spanish, his native tongue, and can still communicate in English, but not as fluent in English since he has been speaking only Spanish for many years.   His principle symptom is memory loss.


Although my father is in good health for a 91 year-old, his dementia has been advancing steadily for at least the four years that I have been monitoring him.  He is still able to manage his many of daily activities, going to bed, getting up, going to the bathroom and walking around the house with the help of his cane or walker.  He can no longer prepare meals and managing steps is a challenge.  Although he could probably bath himself, several of us provide assistance with bathing, shaving and dressing.  Physically, he is able to handle himself well for his age.  His memory, however, has declined steadily in the four years that I have been monitoring him closely.  I am certain that his memory began to be affected earlier than four years ago, but in the last four years he has gone from complete memory recall of all his life – a rich historical memory of 87 years to a point now where his history of his life is only about 10 minutes long.  He can still remember some aspects of his past if you remind him of key events and if he is provided with names of people or clues of events, but he cannot initiate a conversation on any period of his life by himself.  



He still remembers who the immediate family is and remembers we he is speaking to or about in a given conversation, within a ten-minute time-frame.  He remembers his brother, sister-in-law, some nieces and some nephews, if you remind him who they are.  But he has a hard time remembering some of his cousins and other friends.  He can still carry out a conversation, as long as the topics took place in the last ten minutes and only if he is asked direct questions.  Other than “how are you” or comments on immediate observation of the weather or events happening at the moment, he will not initiate a conversation.   He no longer seems to care for the content of a TV program and is perfectly happy looking at the motion of the TV screen without any sound.  Much of the time, when I go to visit him, I find him staring out the window with no expression on his face.  However, my father does not seem to exhibit some of the classical symptoms of dementia I have read or been told about, such as anger, frustration, anxiety or depression that is sometimes reported in dementia patients.  He knows that is unable to remember things, but I don’t think he realizes the extent of his memory loss.  He does express regret for his forgetfulness and may even have some embarrassment. 



Dementia is a terrible disease.  It is probably the worst disease any person can get. It robs the life; the history, the memories and one’s awareness of family.  It slowly dissolves your life.  It is very depressing watching this ailment take his life away very slowly and feeling very frustrated not being able to do anything about it.  The best we can do is keep him company, share stories and events, help him maintain communications with extended family and friends for as long as he is able and help him get around.  In general, keep his mind active.  I fear that the death of brain cells will eventually result in the lack of control in his motor functions as well as continue cognitive decline.



I have made it a point to have conversations with my father on a regular basis, three to four times per week for the past five to six years.  The first couple of years it was both by telephone and in person because he spent much of the winter in Southern Texas.  When he was in Michigan during the summer, I would make it a point to have breakfast with him early in the morning since both he and I are (were) early morning people.  Breakfast was before 7:00 a.m.   I liked the early breakfast schedule because we were almost certain of not being interrupted.  We are a family of 10 siblings and it was difficult to have a serious conversation with him when all of us (or most of us) were gathered.



At first, our conversations consisted of an exchange of the news, or I would present him with ideas on science, nature, and politics.  When he was in Texas, I would mail him articles and/or magazines in Spanish and then we would have a telephone conversation about them.  For example, during our breakfasts we would discuss such things as tectonic plate theory, the difference in the structure of the Mexican and U.S. federal governments, pollution by industry, education programs, etc.  We stayed away from religious topics because our views differ slightly, I am more liberal and he more conservative in religious matters.   He was fascinated to learn new things, especially tectonic plate theory and the reason why volcanoes and earthquakes happen.  In every topic he would always make the comment that “God does everything for a reason.” 



Sometimes in these conversations, he would begin to speak about his life and I began to record him on my smart phone or take notes of his stories that he would recount in great detail.  About four years ago, about 100% of our conversations began to revolve around his family history and we would spend at least a couple of hours on Saturday mornings, in the quiet of the morning, going over and documenting these stories.  His family had such a tragic life and his adventures as a kid were so interesting that I wanted to document them so that my son could read about them.  Eventually, the idea began to evolve that I should document these into a biography so that there will be a written history of his life and leave this information for our kids, nephews, nieces, and grand kids.  It was clear that if I did not document these, the stories would be lost. 



At first, I thought of writing his biography, but I very quickly ran into problems:  First, I had never written a biography before and second, there were huge gaps in the memory of his life.  Moreover, much of the information he gave me could not be verified.  It is not that I did not believe him, but I needed to confirm certain aspects of his stories, correlate them with dates of historical events to verify the chronology of events.  Unfortunately all his relatives his age; cousins, siblings, uncles had died.  There were still a few around and I needed to go and talk to them. 



I spend time looking up historical records to collaborate at some of his stories with events I could find in newspaper records.  I also found information about family in church records as well as talking to family to try to correlate their versions of what actually happen and what life was all about in the early 1930s and 1940s.  It became apparent that all his stories matched with general historical records; the movement of people back and forth across the border during the depression; floods on the Rio Grande corresponding with storms and hurricanes, agricultural growth in Texas and farm workers moving in from Mexico in the late 1930s and 1940s, every story he told correlated with a historical record.  I even found records of people crossing the border and verified that he did cross when he said he did.  However, the stories that he gave were not a complete record of his life, and when I asked him for more information, he did not remember.  It was very frustrating.



I began to look into how we remember things and it turns out that we only seem to remember significant events in our lives.  We don’t remember everything.  We only remember significant things like the first kiss and possibly the events around it; a big sporting event, our first fancy dress or suit, our first fight in school, a teacher that made an impact on our life.  The memory of our life is just a string of events with a lot of empty “space” that our brain thought it was not important enough to save.  Things

 that happen in between these key events are soon forgotten or they fade and become foggy in our minds.  Without a diary, most people only remember a small fraction of their lives.   This memory of life can be illustrated with the following chart:

  Illustrative Map of Dad's Original Memory – about four years ago

In this idealized graph, our memories of our life can be represented bubbles representing key events.  If our whole life is represented by a horizontal line, the memories of key events in our life can be represented by these memory “bubbles.”  The size of the “bubble” can represent the strength of the memory or the amount of information we remember about it.  Some memories can be stronger than others and many, many events in our lives are simply not remembered.  If we apply this hypothetical chart to my father, it would represent his memories four years ago as I began to record and document the stories of his life.  I recorded many of his stories with my smart phone or took detailed notes as he was recounting his adventures to me with names of people and places. 



Every Saturday I would spend a couple of hours with him and he either retold some of the stories or remembered new ones.  A little over two years ago I began to notice that he did not remember some of the details of some of the stories he had told me and some he did not remember at all.  When I questioned him on these and read back some of the things he had told me, he either remembered some of them with much less detail and some he just simply did not remember.  The period he had trouble remembering seem to be stories of the period in the mid years of his life, approximately when he was about 30 years of age to about when he was 60 years old.  That would put the period from about 1955 to 1985.  If we represent this in a similar chart, the following would illustrate this loss by these reduced yellow “bubbles”:




First stage of Reduced Memory – about 2.5 years ago



I spent several Saturdays trying to get him to recount the stories from that period in his life, but they were either never the same as the original versions;  most of them did not have near the detail and many of them he did not remember names, places or events, and some of them he could not recall.  For example, one of the stories related how I had to go to the bathroom during a time he took my aunt to her job (about 1958) and he had to stop on the side of the road so that I could go, and how I would made pictures in the snow with my pee.  He could never remember that event again.  This is one that I can personally corroborate because I remember the event.  Another example was how my Uncle migrated to Michigan and ended up in Pontiac.  In that particular story, I actually noticed and documented how that memory disappeared over a period of a few of months.



What would cause such a loss?  Maybe that period of time might have been very stressful for him and maybe other factors contributing to losing these memories first.  It was a period after we had migrated to the U.S. from Mexico, my mother was pressuring him to go back to Mexico because she did not like it here, he was working two jobs had eight kids and we were all school age.  Maybe other factors dominated his life and the memories of that period might not have been as significant.  Or, maybe the disease began to attack that part of the brain first where those memories resided and were some of the first ones to be erased.  It was clear that those memories were disappearing and they never came back.



By about a year ago (approximately one and one half years ago), the memory loss had affected all the memories from his whole life.  He could recall some events but the amount that he could recall was much diminished.  In our chart it would be represented by the yellow “bubbles” as follows:


 

Second stage of Reduced Memory – about 1.5 years ago



His memories were much diminished now.  He could still remember some aspects of the events but at a much reduced detail and many of them he could not remember at all.   Some of the key events in his more recent life, like the studies and the events leading to his ordination as a Deacon of the Catholic Church.  When I asked him specific questions about names of people and events, he would remember some of them with great difficulty, but many of the names of people and events disappeared from his memory.  In the chart I introduce a memory “bubble” at the end that I color in red.  This represents his current memory.  A year ago, this memory period could be measured in days.  However, it has been reduced little by little to a point where it is now more like about 10 minutes.  If you ask him something that happened more than 10 minutes ago, he will not remember.



About six to eight months ago, I noticed a further reduction in his capacity to remember.  Not only he could not initiate a story when asked, I had to reinforce an event, a name or information several times before he could recall the event, but he could not tell any information about it.  Sometimes I wondered if he just agreed with me that he remembered the event just to please me.  Hard to say, because It was hard for me to be unbiased about it because I wanted him to remember.  If I had to illustrate his capacity to remember it would have to be as follows where the events have now been reduced to a single points with no robust memory about them:



 Third stage of Reduced Memory – about 8 months ago



At this stage, his memories have been reduced to a single word or a single sentence about the event, when he is able to remember the event at all.  His present memory, represented by the small red “bubble” at the end was reduced to about ten minutes.  He is no longer able to carry a conversation about any topic from his past.  He can answer questions when asked directly and express a greeting like “how are you,” but he does not initiate a conversation.  He is no longer able to enjoy a movie or TV program, because the plot takes place in a space of time longer than 10 minutes.  He will enjoy a joke when it is short, and he enjoys short You-Tube videos about people and events.  He is able to have and enjoy telephone conversations with his brother - who is 88 years of age and following the same pattern of memory loss as my father; with his cousins, who are younger than he but also going through similar memory loss; and some nieces and nephews.   In mornings when I have breakfast with him, I make at least one or two phone calls to Mexico and talk to one of his relatives.  We also watch short You-Tube and Facebook videos, and he enjoys and can talk about them as long as it is done during his 10 minute memory period.



Recently, however, in the last several months, he is able to enjoy the conversation but he seems like not to know what to say.  I have noticed that he only does three things in these telephone conversations now:  1)  He will respond to direct questions, if they are not too complicated;  2) He will ask about their health and  3) He will give a blessing to whoever he is talking to.  


More recently, as I sit with him to have breakfast three or four times per week, it has been getting harder to even carry out a conversation where he only has to answer questions.  The questions have to be limited to very conventional things like the weather at that time, the birds and squirrels outside, how difficult it was to sleep last night, when and what he is going to eat.  He knows that he is forgetting things but he does not know the extent of what he has forgotten and how long it has been happening.  He will, however, listen very attentively to information on any topic and understands the concept well and asks questions.  For example, today I spoke to him about Global Warming, how it is caused, what are the consequences, how people will be affected.  He would ask very lucid questions of what we could do about it, what is the “government doing about it and what will happen to all those people who will be displaced in the seashore flooding from the polar ice melt.  Based on several test questions I made to him on Saturday, I estimate his memory profile, in relation to our chart is as follows:






Fourth Stage of Reduced Memory – today



He still remembers a few things about his life, and might even be able to describe, with a sentence or two, some aspect of that event.  But in order to do that he has to be reminded with a lot of facts about that event. 



It is always enjoyable to have breakfast with dad several times a week, but it is getting very hard for me. As I mentioned, for a 91-year old, he is a good health.  But his dementia has been advancing steadily for four years and he has gone from complete memory recall of all his life – a rich historical memory of 87 years four years ago, to a point now where his history of his life is now only about 10 minutes long.  He can still remember some aspects of his past if you remind him of key events.  Also he can still carry out a conversation, as long as you ask him direct questions and the topics discussed took place in the last ten minutes. It is very sad to see this condition in someone who was always very active, very curious, very adventurous, and not afraid to initiate new things. 



Dementia is probably the worse disease that anybody can get.  Physical ailments can either be cured or you die.  Dementia, however, can never be cured, and you still die while you are alive.  You die because  it robs your life; it robs your history; it robs your memories; it robs your knowledge of family, it leaves you with a shell of yourself.  It leaves you lonely, but you don’t know that you are lonely because you don’t have a long enough memory to feel lonely, you don’t have enough memories to feel sad and you grow to be totally dependent on others for everything.    

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